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Current anticoagulation guidelines suggest that optimal anticoagulation duration for unprovoked venous thromboembolism is determined by an individual risk assessment, balancing risks of anticoagulation bleeding with venous thromboembolism recurrence. Among individuals heterozygous for the factor V Leiden mutation
Venous thromboembolism. The primary clinical manifestation of Factor V Leiden is VTE. Risk for a first VTE. The relative risk for VTE is increased 3- to 8-fold in Factor V Leiden heterozygotes (Table 3). Recurrent VTE. Pregnancy complications.
Factor V Leiden. This is caused by a change (mutation) in the gene for this protein. The different gene that makes the Factor V Leiden protein is inherited from one or Heterozygous child. 100% chance: child will inherit 1 copy of the Factor V Leiden gene. Increased risk for clotting. Factor V Leiden is an inherited disorder.
4 Nov 2002 Factor V Leiden increases the risk of venous thrombosis 3- to 8-fold for heterozygous and 30- to 140-fold for homozygous individuals. Anticoagulation is the cornerstone of therapy for venous thromboembolism; the optimal duration of this therapy depends on the balance between the risk of recurrent
Factor V Leiden is the name of a specific mutation (genetic alteration) that results in thrombophilia, or an increased tendency to form abnormal blood clots in blood Women with heterozygous factor V Leiden who are making decisions about OCP or HRT use should take these statistics into consideration when weighing the
4 Dec 2010 This, however, has not turned out to be the case because most individual studies have not found an increased risk of recurrent VTE among heterozygotes with the factor V Leiden or prothrombin G20210A mutations. A pooled analysis of the literature found the risk associated with factor V Leiden mutation to
3 Oct 2017 "Pseudo homozygous" activated protein C resistance due to double heterozygous factor V defects (factor V Leiden mutation and type I quantitative factor V defect) associated with Zehnder JL, Jain M. Recurrent thrombosis due to compound heterozygosity for factor V Leiden and factor V deficiency.
14 Jul 2015 Factor V Leiden — Comprehensive overview covers causes and treatment of this inherited clotting disorder.
Deep venous thrombosis (DVT) is the most common VTE, with the legs being the most common site. Thrombosis in unusual locations is less common. Evidence suggests that a heterozygous factor V Leiden mutation has at most a modest effect on recurrence risk after initial treatment of a first VTE.
     

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